2006-11-13 19:30:52 UTC
blood cells leading to .. **inflammation** ..
Or the 'chronic low grade inflammation' .. noone seems to be able to ..
Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
Vol. 36, No. 4, 2004, pp. 226-230
Bioline Code: ph04075
Full paper language: English
Document available free of charge
Indian Journal of Pharmacology, Vol. 36, No. 4, 2004, pp. 226-230
Acute and chronic effects of aspirin on hematological parameters and
hepatic ferritin expression in mice
Merchant MA, Modi DeepakN
OBJECTIVE: To examine the acute and chronic effects of aspirin on
peripheral blood and bone marrow counts and hepatic ferritin expression
in mice. MATERIAL AND METHODS: Adult male albino mice were orally
administered aspirin at a dose of 600 mg/kg thrice daily for 7 days or
150 mg/kg once daily for 6/7 days up to 25 weeks. At the end of the
experiment the red and white blood cell counts, hemoglobin, and packed
cell volume were estimated. Bone marrow films were studied to estimate
the rate of erythropoiesis and leucopoiesis. Expression of liver
ferritin was tested by immunohistochemistry. RESULTS: Acute or chronic
doses of aspirin reduced the RBC count, hemoglobin and other red cell
indices as compared to controls. The WBC counts were higher in the
treated animals as compared to the untreated animals. Both the
treatment regimens appeared to suppress the rate of erythropoiesis in
the marrow, while the rate of leucopoiesis appeared to increase in the
marrow of the treated animals. Aspirin treatment did not significantly
affect the expression of ferritin in the liver. CONCLUSION: Aspirin in
either acute or chronic doses induces anemia associated with
leucocytosis in mice; the anemia does not seem to be induced due to
alterations in iron metabolism. The drug appears to use multiple
targets which affect red cell production and maturation processes.
Acetyl salicylic acid, hematological toxicity, red cell indices
© Copyright 2004 Indian Journal of Pharmacology.
Alternative site location: http://www.ijp-online.com
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